[Feasibility of combined roentgeno-radionuclide studies of the lungs in preventive mass screening of workers in an industrial enterprise]. / Vozmozhnosti kompleksnogo rentgenoradionuklidnogo issledovaniia legkikh pri massivom profilakticheskom osmotre rabochikh promyshlennogo predpriiatiia.

The results of a combined roentgeno-radionuclide investigation of the lungs were studied in 45 persons at risk of developing chronic nonspecific pulmonary diseases, diagnosed in a mass screening of 3000 workers at an industrial enterprise. The results of fluorographic, roentgenoscopic and roentgenographic investigations of the lungs, roentgeno-pneumopolygraphy and radionuclide investigation of lung perfusion (pulmoscintigraphy with 99mTc-labeled albumin macroaggregates) were compared. During this combined investigation the signs of nonspecific pulmonary diseases were diagnosed in 40% of the patients, changes of the pulmonary blood flow--in 71%, changes in ventilation--in all the examinees. A conclusion was made of the necessity of additional combined investigation of patients belonging to risk groups, identified during mass screenings.

[Radionuclide study of the bone marrow using 99mTc-coren in patients with polycythemia vera]. / Radionuklidnoe issledovanie kostnogo mozga s 99mTc-korenom u bol'nykh istinnoi politsitemiei.

The results of radionuclide investigation of the bone marrow in 44 patients (of them 32 with polycythemia vera) were presented. The informative value of bone marrow scintigraphy and whole-body radiometry using 99mTc-coren was shown in the patients with polycythemia vera at advanced stages. The results obtained made it possible to specify a clinical stage and prognosis of disease, and to optimize therapy.

[Bone marrow scintigraphy with 111In-citrin in the diagnosis of hemoblastoses]. / Stsintigrafiia kostnogo mozga s 111In-tsitrinom v diagnostike gemoblastozov.

Bone marrow scintigraphy with 111In-citrin was used to investigate 55 patients with varying hemoblastoses. The high informative value of the method was shown in extended stages of polycythemia vera, lymphogranulomatosis, multiple myeloma and in leukemia. The method enables assessment of the morphofunctional state of the whole solid mass of the hemopoietic tissue. The data of bone marrow scintigraphy with 111In-citrin can be useful in determination of the disease stage, optimum scheme of its treatment, the therapeutic effectiveness control and prognosis of hemoblastoses.

[2-isotope study in the diagnosis of thyroid cancer]. / Dvukhizotopnoe issledovanie v diagnostike tireoidnogo raka.

Altogether 54 patients with thyroid nodal lesions (40 of them had thyroid carcinoma) were investigated by 75Se-methionine and a thyrotropic RP. 75Se-methionine turned out to be inappropriate for differential diagnosis of benign and malignant thyroid lesions because of many false-negative results. The combination of positive scanning with 75Se-methionine and 99mTc-pertechnetate (or 131I) raised the diagnostic informative value of the method.

[Scintigraphy in the evaluation of postoperative disorders of pulmonary circulation in cancer of the breast and genitalia]. / Stsintigrafiia v otsenke posleoperatsionnykh narushenii legochnogo krovotoka pri rake molochnoi zhelezy i genitalii.

Altogether 60 patients with genital tumors and breast cancer were examined on the 3rd-7th day after operation using ON-110 gamma-camera (USA). Perfusion pulmonary scintigraphy with labeled MMA was performed in all the patients. In 66% of the examinees pulmonary blood flow disorders localized mainly in the lower part of the lungs, were noted, and in breast cancer patients--on the tumor lesion side, too. Perfusion pulmonary scintigraphy was shown to be an informative method of diagnosis of postoperative changes of the capillary pulmonary circulation which were clinically undetectable.

[Radionuclide research on liver and kidney function in thyroid cancer after radioiodine therapy]. / Radionuklidnye issledovaniia funktsii pecheni i pochek pri rake shchitovidnoi zhelezy posle radioiodoterapii.

A study was made of liver and renal function using radionuclide methods in 51 thyroid cancer patients on radio-iodine therapy. Multimodality examination of the patients revealed no clinical manifestations of hepatocellular and renal failure even in significant therapeutic activities up to 40 GBq and more. Hepatography and renography showed a decrease in absorptive and secretory hepatocytic function, an increase in the period of hippuran half-life and a decrease in total renal function. The revealed changes were of moderate nature, stable and related both to hypothyrosis and a radiation factor.

[Scintigraphy of the bone marrow using 111In citrin in the diagnosis of hematopoietic disorders following chemotherapy]. / Stsintigrafiia kostnogo mozga s 111In-tsitrinom v diagnostike narushenii gemopoéza posle khimioterapii.

Diagnostic potentialities of the use of a new radiopharmaceutical 111In-citrin were studied to assess the hemopoietic status on the basis of examination of 47 cancer patients after chemotherapy. Bone marrow function was assessed on the basis of the visual RP distribution in the bone marrow and a study of quantitative indices of the agent accumulation in various anatomical regions. The results of the study showed that a decrease in the agent accumulation in the flat pelvic bones was determined in patients with stable hemocytopenia. Hyperfixation of the agent was undetectable in the long tubular bones. Raised accumulation of the indicator in the metaepiphyses of the long tubular bones was observed in parallel with lowered accumulation of the agent in the flat bones in the group of patients without hemocytopenia nearly in half of the cases. The accumulation of RP in the rest of the cases did not differ from that in the control group. The results obtained showed that 111In-citrin accumulation in the bone marrow of the long tubular bones indicating its functional rearrangement and the normal level of the indicator accumulation in the main zones of bone marrow hemopoiesis in cancer patients could serve as a favorable prognostic sign for the assessment of hemopoiesis in subsequent courses of cytostatic therapy.

[Scintigraphy of the bone marrow with 111In-citrin in polycythemia vera]. / Stsintigrafiia kostnogo mozga s 111In-tsitrinom pri istinnoi politsitemii.

Scintigraphy of the bone marrow with 111In-citrin was performed in 32 patients with polycythemia vera and 8 controls. The method ensured an objective assessment of bone marrow function in patients with polycythemia vera. A characteristic RP scintigraphic picture corresponded to different clinical stages of the disease. A degree of a decrease in the blood radioactivity within 24 h after i. v. administration of 111In-citrin reflected the summary erythropoietic activity of the bone marrow and could serve as a differential diagnostic criterion in determining a stage of polycythemia vera.